VETERİNER DOZAJ FORMUNDA İKİ ANTELMİNTİK İLACIN EŞZAMANLI KANTİTATİF ANALİZİ

In this research article, a new chromatographic method ultra-performance liquid chromatography (UPLC) was developed for the quantification of ivermectin (IMT)-preziquantel (PRZQ) in two-component mixture and veterinary dosage form mixture. The separation studied drugs (IMT PRZQ) carried out on Waters Acquity ® BEH C18 column (50mm x 2.1 mm i.d., 1.7 m) using mobile phase consisting water-acetonitrile-methanol (10:70:20, v/v). analysis, flow rate 0.38 mL/min, temperature maintained at 42 0C. detection IMT PRZQ made wavelength 220.0 245.0 nm, respectively. UPLC validated applied to real samples PRZQ. Recovery assay results were found be 100.4 % 101.8 IMT. presented is introduced as an alternative choice quality control pharmaceutical preparations containing these drugs. For drugs, experimental analysis choice.